Skip to main content
. Author manuscript; available in PMC: 2021 Oct 13.
Published in final edited form as: J Am Chem Soc. 2020 Dec 31;143(2):705–714. doi: 10.1021/jacs.0c06115

Figure 1.

Figure 1.

(a) Natural products inspiring the library design. (b) The portion of natural product cyclic peptides from the Natural Products Atlas comprised of lariat peptides and the portion of lariat peptides comprised of ester-cyclized lariats. (c) Design of Library 1. (d) Schematic of the split-pool library synthesis. (e) Synthesis of Library 1: (i) solid-phase peptide synthesis; (ii). Fmoc-Pro-OH, DIC, DMAP; (iii) piperidine, DBU; (iv) HFIP; (v) COMU, DIPEA.