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. Author manuscript; available in PMC: 2021 Oct 13.
Published in final edited form as: J Am Chem Soc. 2020 Dec 31;143(2):705–714. doi: 10.1021/jacs.0c06115

Figure 6.

Figure 6.

Effect of threonine position on permeability. The molecular weight and AlogP are constant among these libraries. Library 3 has one fewer N-methyl group than the other three libraries. To maintain consistency with library 1, degree of methylation refers to the total number of N-methyl groups minus one. Within each degree of methylation, all compounds are isomeric. The red dashed lines represent medians and the boxes represent quartiles.