. 2021 Sep 4;8(10):ofab462. doi: 10.1093/ofid/ofab462

Table 2.

Details on Clinical and Genotypic Features of 19 Transplant Recipients With Induced Ganciclovir Resistance Mutations in the CMV UL97 Gene

Patient	Tx Type	Pre-tx Donor/Recipient CMV IgG	Clinical Presentation	Codon in Amino Acid							No. of Induced GRMs/Patient
				460 I/V	520 Q	594 V/G	595 S/F	596 G	603 W	607 Y/F
1	MAC	D-/R+	CMV colitis, retinitis, and suspected pneumonia							++^a	2
2	MAC	D-/R+	CMV colitis						++		1
3	MAC^b	D-/R-	CMV retinitis	++				++			2
4	MAC^b	D-/R+	CMV colitis			++	++				2
5	MAC	D-/R+	None proven			++					1
6	NMA	D-/R+	CMV colitis			++					1
7	Liver	D+/R-	CMV pneumonia		++				++		2
8	Liver	D+/R-	Asymptomatic						++		1
9	Liver	D+/R-	Asymptomatic						++		1
10	Lung	D+/R-	CMV pneumonia				++				1
11	Lung	D+/R-	CMV colitis				++				1
12	Kidney	D+/R-	Asymptomatic			++			++	++	3
13	Kidney	D+/R-	Asymptomatic				++				1
14	Kidney	D+/R-	Asymptomatic		++	++			++		3
15	Kidney	D+/R-	CMV pneumonia			++^a	++				3
16	Kidney	D+/R-	Asymptomatic				++				1
17	Kidney	D+/R+	Asymptomatic				++				1
18	Kidney	D+/R-	Asymptomatic	++							1
19	Kidney	D+/R-	Asymptomatic				++				1
No. of patients with mutation				2/19	2/19	6/19	8/19	1/19	6/19	2/19
% with mutation induced				10.5	10.5	31.6	42.1	5.3	31.6	10.5

Patient number corresponds to numbering in Figure 3A.

Abbreviations: CMV, cytomegalovirus; D, donor; GRMs, ganciclovir resistance mutations; HSCT, hematopoietic stem cell transplantation; MAC, myeloablative conditioning regimen; NMA, nonmyeloablative conditioning regimen; R, recipient; SOT, solid organ transplantation; Tx, transplantation; UCB, umbilical cord blood.

^aBoth mutation in same codon.

^bPediatric patients.