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. 2020 Mar 31;224(7):1128–1138. doi: 10.1093/infdis/jiaa144

Figure 1.

Figure 1.

RTS,S-induced IgG and IgM target the central and C-terminal regions of CSP. Serum from adults vaccinated with RTS,S collected at baseline (D0, n = 45), and PV1 (n = 45), PV2 (n = 43), and PV3 (n = 33) were tested for IgG (A) and IgM (C) to full-length CSP, and those collected PV3 (B, D) were also tested against peptides representing the central repeat and C-terminal regions of CSP (NANP and Pf16, respectively). Samples were tested in duplicate and the mean value was graphed, along with the group median and IQR for participants who were not protected (NP, n = 17) and protected (P, n = 16) against controlled human malaria infection challenge. Reactivity between paired samples collected at different time points was compared using the Wilcoxon matched pairs signed rank test, and reactivity between unpaired NP and P groups was compared using the Mann-Whitney U test. Abbreviations: CSP, circumsporozoite protein; IgG, immunoglobulin G; IgM, immunoglobulin M; IQR, interquartile range; OD, optical density; PV1, post vaccine dose 1; PV2, post vaccine dose 2; PV3, post vaccine dose 3.