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. 2020 Mar 31;224(7):1128–1138. doi: 10.1093/infdis/jiaa144

Figure 5.

Figure 5.

Relationship between functional antibodies and protection against CHMI. Serum from adults vaccinated with RTS,S collected post vaccine dose 3 (n = 33) were tested for C1q-fixation and FcγRIIa and FcγRIII-binding to full-length CSP. Participants were defined as having high or low activity (function scores of 1 and 0, respectively) for each functional antibody response type based on the median OD values: C1q = 0.621, FcγRIIa = 2.127, and FcγRIII = 0.655. A, Heat-map of participants with high and low antibody activity who were protected or not protected against CHMI challenge (rows represent the individual subject). B, Kaplan-Meier survival curves of individuals with high and low activity for each functional antibody response type and malaria status during 28 days follow-up, and (C) of individuals with high activity for at least 1 functional antibody response type or low for all functional responses (total function scores of 0 and ≥ 1, respectively). Kaplan-Meier survival curves were analyzed using the Gehan-Breslow-Wilcoxon test. Abbreviations: CHMI, controlled human malaria infection; CSP, circumsporozoite protein; OD, optical density.