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. 2020 Apr 2;224(7):1257–1265. doi: 10.1093/infdis/jiaa157

Figure 4.

Figure 4.

Transmission to Anopheles mosquitoes by direct skin feeding or by membrane feeding of venous blood samples. A total of 71 direct feeding assays (DFAs) were conducted (median, 31 examined mosquitoes per experiment; interquartile range [IQR], 28–32), alongside 71 direct membrane feeding assays (DMFAs) (exactly 25 examined mosquitoes per experiment) and 71 DMFA experiments after gametocyte concentration by magnetic-activated cell sorting (DMFA-MACS; median: 18 mosquitoes examined per experiment; IQR, 16–19). For 1 participant in arm 1, feeding experiments at the first time point were not performed owing to undetectable gametocytemia. A, Total proportion of individuals infectious to mosquitoes by DFA, DMFA, and DMFA-MACS, during the study. B, Number of oocysts per mosquito in DFA, DMFA, and DMFA-MACS feeding experiments. C, D, Proportion of infected mosquitoes per individual per time point by treatment 3 (T3) treatment group (high-dose piperaquine [PQP; arm 3] or sulfadoxine-pyrimethamine [SP; arm 4], day 21) in DFA or DMFA-MACS. T3 was initiated immediately after the feeding experiments on day 21, feeding experiments on days 24 and 29 are after T3.