Table 2.
Course of Treatments, Parasitemia, and Infectivity to Mosquitoes for Different Inoculation Groups
| Median Value (Range)a | |||
|---|---|---|---|
| Variable | MB Inoculation | IBSM | P Value |
| Time to first detection of asexual parasites, d | 7.0 (6.5–16.5) | 5.0 (4.0–5.0) | <.001 |
| Time to T1, d | 12.25 (7.5–19.50) | 8 | NA |
| Participants receiving T2, % (no./total) | 50 (6/12) | 42 (5/12) | .50 |
| Time between T1 and T2, d | 2.00 (1.75–6.50) | 6.25 (4.25–12.50) | .02 |
| Peak parasite density, parasites/mLb | 32 807 (2428–53 203) | 27 700 (3262–271 790) | .48 |
| Prevalence of gametocytes, % (no./total) | 92 (11/12) | 100 (12/12) | .50 |
| Peak gametocyte density, gametocytes/mLb | 14.2 (2.5–727.9) | 1304 (179–3826) | <.001 |
| Area under the curveb | |||
| Total parasitemia | 37 654 (4260–103 994) | 38 639 (3067–303 669) | .98 |
| Gametocytemia | 99 (16.6–5330) | 11 043 (1643–37 326) | <.001 |
| Time between infection and gametocyte detection, d | 21.0 (20.0–27.0) | 14.0 (13.0–16.0) | <.001 |
| Time to gametocyte detection, dc | 14.0 (10.0–20.0) | 9.0 (8.0–11.0) | <.001 |
| Individuals infectious to mosquitoes, % (no./total) | 0 (0/12) | 75 (9/12) | <.001 |
Abbreviations: AUC, area under the curve; IBSM; induced blood-stage malaria; MB; mosquito bite; NA, not applicable; T1, first subcurative treatment; T2, second subcurative treatment.
aData represent median (range) unless otherwise specified.
bPeak parasitemia and AUC total parasitemia were defined by means of18S quantitative polymerase chain reaction; peak gametocyte density and AUC gametocytemia were defined based on the sum of ccp4 female-specific and pfmget male-specific values at quantitative reverse-transcription polymerase chain reaction.
cRelative to first detection of asexual parasites.