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Schematic diagram of an alternative splicing process and its relative function in metastasis. (a) The five different alternative splicing types. (b) DNA methylation or histone methylation influenced the production of alternative splicing. (c) Alternative splicing is involved in every step of metastasis, from primary tumor cells invading adjacent tissues to moving to new sites, surviving in the circulation, and adapting to distant tissues to form secondary tumor (colonization).
