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. 2021 Oct 14;19:244. doi: 10.1186/s12916-021-02110-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Projected epidemiological impact of a comprehensive one-time intervention to find and treat TB and LTBI. The projected TB incidence rate (A) and TB-related mortality rate (B), per 100,000 per year between 2000 and 2040, in model simulations without the intervention (gray) and in simulations with the intervention implemented in 2020 (red). Percentage reductions in annual TB incidence (C) and TB-related mortality (D) rates (red). Also shown are simulated interventions which (hypothetically) focused solely on treating adults for LTBI with no effect on active TB, represented by adult preventive therapy (PT) in Fig. 3 (blue), or focused solely on active case finding (ACF) and child contact tracing (CCT), represented by ACF and CCT arms in Fig. 3 (yellow). The cumulative impact is shown as cumulative TB cases averted (E) and cumulative TB-related deaths averted (F), for the full rapid one-time intervention (red) and for its PT (blue) and ACF/CCT (yellow) components separately