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. 2021 Oct 14;19:244. doi: 10.1186/s12916-021-02110-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — The impact of a comprehensive one-time intervention supplemented by follow-up health system strengthening. The TB incidence rate (A) and TB-related mortality (B) rate, per 100,000 per year between 2000 and 2040, in model simulations without the intervention (gray), and with a one-time intervention implemented in 2020, including medium-term health system strengthening after 2020 (violet). Percentage reductions in TB incidence (C) and TB-related mortality (D) rates (darker burgundy). Also shown for comparison are reductions with the one-time intervention only (lighter red). Cumulative cases of TB (E) and cumulative TB-related deaths (F) averted per 1 million by the full intervention (burgundy); the cumulative impacts of the one-time intervention alone are also shown for comparison (red)