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. 2021 Jul 10;34(11):1979–1989. doi: 10.1038/s41379-021-00869-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Comparisons of the overall survival (OS) between three patients with high total mutational burden (TMB-high; ≥10 mut/Mb) and 11 cases with TMB-low (a) between six patients harboring a TP53 mutation and eight without this mutation (b) or between seven patients harboring a TP53 or RB1 mutation and seven patients without these mutations (c).