Table 2.

Pathological analysis for 24 resected/biopsied specimens.

Sample ID	Available tumor specimen	Tumor location	Pathological subtype	Mixture of squamous cell carcinoma component	Ki-67 index	p16 expression	Rb expression	p53 overexpression	RB1 mutation	TP53 mutation
1	Biopsy	Paranasal sinus	SCC	No	NA	NA	NA	Pos	Not analyzed	Not analyzed
2	Biopsy	Oral	LCNEC	No	66%	NA	Pos	Pos	Neg	Neg
3	Biopsy	Nasal cavity	SCC	No	81%	NA	Neg	NA	Pos	Pos
4	Biopsy	Oropharynx	LCNEC	No	85%	Pos	Neg	Pos	Pos	Neg
5	Biopsy	Nasal cavity	SCC	No	NA	NA	NA	Pos	Not analyzed	Not analyzed
6	Biopsy	Paranasal sinus	LCNEC	Yes	91%	NA	Neg	Pos	Neg	Neg
7	Resection	Paranasal sinus	LCNEC	No	NA	NA	NA	Neg	Not analyzed	Not analyzed
8	Biopsy	Paranasal sinus	LCNEC	No	99%	NA	Neg	Pos	Neg	Pos
9	Biopsy	Larynx	SCC	No	NA	NA	NA	NA	Not analyzed	Not analyzed
10	Biopsy	Hypopharynx	SCC	No	NA	NA	NA	NA	Not analyzed	Not analyzed
11	Biopsy	Paranasal sinus	LCNEC	No	72%	NA	Pos	Pos	Neg	Neg
12	Biopsy	Hypopharynx	SCC	No	NA	NA	NA	NA	Not analyzed	Not analyzed
13	Biopsy	Paranasal sinus	LCNEC	No	84%	NA	Neg	Pos	Pos	Pos
14	Biopsy	Nasal cavity	SCC	No	64%	NA	Pos	Pos	Neg	Neg
15	Resection	Salivary gland	SCC	No	59%	NA	Pos	Pos	Neg	Pos
16	Biopsy	Nasal cavity	SCC	No	NA	NA	NA	NA	Not analyzed	Not analyzed
17	Biopsy	Paranasal sinus	LCNEC	No	NA	NA	Neg	Pos	Not analyzed	Not analyzed
18	Resection	Oropharynx	LCNEC	No	87%	Neg	Pos	Pos	Neg	Neg
19	Biopsy	Oropharynx	LCNEC	No	92%	Pos	Pos	Pos	Neg	Neg
20	Biopsy	Oropharynx	LCNEC	No	93%	Neg	Pos	Pos	Neg	Neg
21	Resection	Salivary gland	LCNEC	No	NA	NA	Pos	Pos	Not analyzed	Not analyzed
22	Resection	Paranasal sinus	LCNEC	Yes	96%	NA	Pos	Pos	Neg	Pos
23	Biopsy	Oropharynx	SCC	No	NA	Neg	NA	Pos	Not analyzed	Not analyzed
24	Resection	Larynx	LCNEC	No	60%	NA	Pos	Pos	Neg	Pos

SCC small cell carcinoma, LCNEC neuroendocrine large cell carcinoma, NA not available, Pos positive, Neg negative.