Table 2.
Effect of PEA on body weight gain and blood biochemistry index in MIA-induced OA rats
| NOR | CON | PEA50 | PEA100 | DiC | |
|---|---|---|---|---|---|
| Initial body weight (g) | 180.9 ± 2.9 | 180.7 ± 2.8 | 180.9 ± 1.6 | 180.9 ± 3.2 | 180.7 ± 1.1 |
| Final body weight (g) | 376.3 ± 7.3 | 372.0 ± 4.3 | 365.7 ± 5.4 | 360.0 ± 6.3 | 355.7 ± 5.1# |
| Body weight gain (g) | 195.4 ± 7.0 | 191.4 ± 5.3 | 184.8 ± 6.1 | 179.1 ± 6.4 | 175.0 ± 5.2# |
| Glucose (mg/dL) | 168.1 ± 11.7 | 182.9 ± 12.6 | 177.9 ± 11.9 | 167.7 ± 5.0 | 142.7 ± 9.2# |
| Triglyceride (mg/dL) | 62.5 ± 4.8 | 105.0 ± 7.2*** | 87.6 ± 6.6 | 83.7 ± 5.8# | 92.6 ± 8.7 |
| Total cholesterol (mg/dL) | 58.3 ± 1.1 | 60.4 ± 2.6 | 57.1 ± 1.4 | 60.2 ± 1.4 | 61.1 ± 1.9 |
| BUN (mg/dL) | 11.7 ± 0.6 | 13.1 ± 0.4 | 13.9 ± 0.4 | 14.0 ± 0.6 | 13.7 ± 0.5 |
| AST (U/L) | 120.0 ± 15.3 | 143.9 ± 13.6 | 94.6 ± 4.2## | 103.1 ± 7.3# | 105.7 ± 6.9# |
| ALT (U/L) | 38.6 ± 3.1 | 42.3 ± 3.7 | 38.8 ± 2.1 | 36.7 ± 1.3 | 38.0 ± 6.9 |
Values are expressed as mean ± SEM (n = 10) *P < 0.05, **P < 0.01, ***P < 0.001 significantly different from the NOR group. #P < 0.05, ##P < 0.01, ###P < 0.001 significantly different from the CON group
BUN blood urea nitrogen, AST aspartate aminotransferase, ALT alanine aminotransferase, PEA palmitoylethanolamide, OA osteoarthritis, MIA monosodium iodoacetate, NOR normal control group (injected with saline + treated with phosphate-buffered saline (PBS)), CON control group (injected with MIA + treated with PBS), PEA50 or PEA100 50 or 100 mg/kg body weight (BW)/day PEA-treated group (injected with MIA + treated with 50 or 100 mg of PEA/kg BW/day), DiC positive control group (injected with MIA + treated with 6 mg of diclofenac/kg BW/day)