Table 3.

Effect of PEA on knee thicknesses in MIA-induced OA rats

	NOR	CON	PEA50	PEA100	DiC
Left (normal) knee thicknesses (mm)	10.56 ± 0.14	10.60 ± 0.07	10.41 ± 0.14	10.54 ± 0.12	10.28 ± 0.03
Right (OA) knee thicknesses (mm)	10.47 ± 0.07	12.37 ± 0.11***	11.88 ± 0.24	11.92 ± 0.14#	11.19 ± 0.11###
Right knee/left knee ratio	1.00 ± 0.01	1.17 ± 0.01***	1.14 ± 0.02	1.13 ± 0.01#	1.09 ± 0.01###

Values are expressed as mean ± SEM (n = 10). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 significantly different from the NOR group. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 significantly different from the CON group

PEA palmitoylethanolamide, OA osteoarthritis, MIA monosodium iodoacetate, NOR normal control group (injected with saline + treated with phosphate-buffered saline (PBS)), CON control group (injected with MIA + treated with PBS), PEA50 or PEA100 50 or 100 mg/kg body weight (BW)/day PEA-treated group (injected with MIA + treated with 50 or 100 mg of PEA/kg BW/day), DiC positive control group (injected with MIA + treated with 6 mg of diclofenac/kg BW/day)