Exercising in the heat appears to affect the efficacy of many dietary supplements, suggesting that findings from research conducted on certain supplements in thermoneutral conditions are not necessarily transferrable to other environmental conditions.

Certain supplements, such as caffeine and nitrate, lack sufficient data to support their use as ergogenic aids in the heat, despite their efficacy in thermoneutral conditions, with caffeine also increasing core temperature responses. Some amino acids might offer the greatest performance benefits in the heat.

A potential risk is posed to those in physical performance domains (i.e., athletes or military personnel) due to the limited guidance on how to supplement appropriately for endurance exercise in hot environments.