Table 2.
Baseline treatment using angiotensin-converting enzyme inhibitors/angiotensin receptor blockers and other concomitant pharmacological treatment before and after the starting on angiotensin receptor blockers - neprilysin inhibitors. Angiotensin-converting enzyme inhibitor = ACEI; Angiotensin receptor blocker = ARB; Angiotensin receptor blocker-neprilysin inhibitor = ARNI.
| Treatments before the start of ARNI and SGLT2i | Number of Patients (percentage) |
|---|---|
| Guideline-driven Medical therapy | |
| Pre-study use of ACEI | 72.1 |
| Pre-study use of ARB | 26.3 |
| During the study use of ARNI | 79.01 |
| Loop diuretics | 100 |
| Beta-blockers | 97 |
| Mineralocorticoid receptor antagonist | 88 |
| Ivabradine | 58 |
| Digoxin | 56 |
| Amiodarone | 12 |
| Device- based therapy | |
| ICD | 11 |
| CRT- p | 5 |
| CRT- D | 2 |
| No- device | 82 |