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. 2021 Oct 13;12:5977. doi: 10.1038/s41467-021-26176-0

Fig. 6. Schematic for p107 regulating muscle progenitor (MP) proliferation based on Sirt1 activity.

Fig. 6

When the cytoplasmic NAD+/NADH ratio is high, Sirt1 is active interacting with p107 preventing its mitochondrial localization. This causes de-repression of the mitochondrial-encoded genes, thus enhancing Oxphos generation that increases MP proliferation rate. Contrarily, with low NAD+/NADH ratio, Sirt1 is inactive and p107 is free to relocate to the mitochondria, where it interacts with the mitochondrial DNA to repress its gene expression. This causes downregulation of mitochondrial Oxphos that decelerates MP cell cycle progression and proliferation rate.