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. 2021 Oct 13;12(10):943. doi: 10.1038/s41419-021-04214-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — In unilateral ureteral obstruction (UUO)-induced tubular damage, A LTPB4 provokes angiogenesis for tissue repair via VEGF and CD31 elevation and in addition to limiting mitochondrial shortness. B LTBP4 deficiency in proximal tubules causes a reduction in VEGF and CD31 expression, along with subsequent aberrant angiogenesis and severe mitochondrial shortness, which eventually accelerates tubular interstitial fibrosis.