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. 2021 Oct 13;11:20358. doi: 10.1038/s41598-021-99852-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Characteristics of B2M-ADCs. (A) Internalization rate of the unconjugated B2M antibody in Control EJp16 cells as measured by CypHer5E fluorescence in a FACS analysis. Results show mean ± SD of three independent experiments. Results show mean ± SD of three independent experiments. (B) Size-Exclusion Chromatography characterization of the purity of the final ADC mix, compared to pure antibody and PBS. (C) SDS page comparing 1 µg of the unconjugated B2M antibody (UC) to an aliquot of the B2M ADC. (D) Quantitation of Drug-Antibody Ratios (DAR) of the B2M conjugated antibodies. Numbers indicate percentages of each DAR population in the mixture. Average DAR: 2.02.