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. 2021 Oct 13;12:5981. doi: 10.1038/s41467-021-26269-w

Fig. 3. MDL-loaded micelles repress melanoma growth.

Fig. 3

Inhibition of B16 melanoma growth by peritumorally injected MDL-loaded micelles in A C57BL/6 mice, B B6.RAG−/− and C DEREG mice. Mice were inoculated s.c. with B16-OVA tumor cells and received peritumoral micelle injections every other day starting from day 4 after inoculation. A Representative results of three independent experiments shown as mean ± SEM, Ctrl (white) n = 5, L-PM (red) n = 6, NL-PM (blue) n = 5, ***P = 0.000988 (day 9), ***P = 0.000989 (day 11), ***P = 0.00099 (day 13), ***P = 0.00098 (day 15) (parametric unpaired two-sided t-test with Holm–Šídák-corrected P values, alpha = 0.05, 0.95 confidence interval). B Representative results of three independent experiments shown as mean ± SEM, n = 5 per group, P-values did not reach statistical significance (parametric unpaired two-sided t-test with Holm–Šídák-corrected P values. C Some mice received additional diphtheria toxin (DT) injections at days 7, 14, and 18 (arrows). Representative results of two independent experiments shown as mean ± SEM, Ctrl (white) n = 5, L-PM (red) n = 4, DT (orange) n = 4, DT+L-PM (violet) n = 5, Ctrl vs. L-PM: ***P = 0.00098 (day 15); Ctrl vs. DT: **P = 0.007 (day 12), ***P = 0.00098 (day 15); DT vs. DT+L-PM: ***'P = 0.000998 (day 18), ***P=0.000997 (day 20), ***P = 0.00098 (day 23), ***P = 0.00099 (day 25) (parametric unpaired two-sided t-test with Holm–Šídák-corrected P values, alpha = 0.05, 0.95 confidence interval).