Table 1.
Diameter (nm) | Z-average (nm)c | PDIc | C total (mg/mL)d | C MDL (mg/mL)e | Drug load (%) | ||
---|---|---|---|---|---|---|---|
Cryo-TEMa | MA DLSb | ||||||
L-PM | 61 ± 12 | 75.8 | 72.1 ± 0.7 | 0.07 ± 0.02 | 120 | 11.15 | 9.29 |
NL-PM | n.d. | n.d. | 97.8 ± 1.8 | 0.25 ± 0.02 | 64 | 0 | 0 |
Errors indicate one std. deviation of multiple measurements (if applicable).
aAs determined by measuring two perpendicular axes of 33 particles with ImageJ.
bAs determined by multi-angle DLS (MA DLS).
cAs determined by single-angle Dynamic Light Scattering (SA DLS).
dAs determined by lyophilization of a portion of injected solutions.
eAs determined by HPLC.