Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 13;12(10):942. doi: 10.1038/s41419-021-04249-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — A Immunoprecipitation (IP) analysis demonstrating an interaction between GRP78 and IRE1α as well as GRP78 and S100A16 after treatment with BAPTA-AM (10 μM) in normal and S100A16-overexpressing HK-2 cells. B Quantitation of IRE1α and S100A16 protein expression in A, normalized to GRP78 expression. Bars are means ± SE from four independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001. C Schematic of the interaction between S100A16 and GRP78 and activation of endoplasmic reticulum stress-mediated through the IRE1α/XBP1 pathway in renal tubulointerstitial fibrosis.