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. 2021 Oct 13;4:1196. doi: 10.1038/s42003-021-02728-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Thirteen mAbs were diluted serially and pre-incubated with pseudotyped SARS-CoV-2 variants at 37 °C for 1 h, then added to Huh-7 cell cultures. The heat map shows of mean ID₅₀ ratio compared with D614G. The results were obtained from three independent experiments. Red indicates increased neutralization activity and blue indicates decreased neutralization activity, as shown in the scale bar. b Structural modelling of the K417N/T, L452R, Y453F, S477N, E484K and N501Y mutations, based on 7chh for X593, RBD-7B8 for 7B8, RBD-Ab1 for 10D 12, and 7c01 for CB6.