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. 2021 Oct 13;11:20332. doi: 10.1038/s41598-021-98684-4

Table 3.

The influence of stress on depression as a function of differential susceptibility genotype.

b se t pr. <  min max
Age (years) 0.003 0.005 0.640 0.520 − 0.007 0.013
Sex (male)
 Female 0.052 0.020 2.650 0.008 0.013 0.090
Race-ethnicity (NH White)
 NH Black − 0.152 0.161 − 0.950 0.344 − 0.467 0.163
 Native American 0.042 0.221 0.190 0.848 − 0.390 0.475
 Asian 0.018 0.138 0.130 0.898 − 0.252 0.288
 Hispanic 0.030 0.064 0.460 0.644 − 0.096 0.156
Education (< high school)
 High school − 0.224 0.062 − 3.610 0.000 − 0.346 − 0.102
 Some college − 0.235 0.058 − 4.010 0.000 − 0.349 − 0.120
 College graduate − 0.275 0.060 − 4.610 0.000 − 0.392 − 0.158
 Post baccalaureate − 0.276 0.062 − 4.450 0.000 − 0.398 − 0.155
Stress exposure (0–5) 0.181 0.012 15.490 0.000 0.158 0.204
Environmental sensitivity PGS − 0.011 0.014 − 0.780 0.438 − 0.039 0.017
Stress*PGS 0.026 0.012 2.100 0.036 0.002 0.049
Genetic ancestry
 PC1 0.048 0.063 0.760 0.448 − 0.076 0.172
 PC2 0.026 0.027 0.940 0.347 − 0.028 0.079
 PC3 − 0.021 0.018 − 1.180 0.238 − 0.055 0.014
 PC4 0.003 0.011 0.280 0.779 − 0.019 0.025
 PC5 0.000 0.009 − 0.010 0.995 − 0.019 0.018
Intercept 1.506 0.198 7.610 0.000 1.118 1.893

Results of primary interest are boldfaced. Reference category in brackets. Cell entries are as follows: b = unstandardized OLS regression estimates; se = standard error; t = test statistic; pr. ≤  two-tailed p-values; min and max = boundaries of the 95% confidence intervals. All data are weighted to reflect the design of the Add Health Study.