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. 2021 Oct 13;11:20332. doi: 10.1038/s41598-021-98684-4

Table 4.

The influence of stress on depression as a function of major depressive disorder PGS.

b se t pr. <  min max
Age (years) 0.004 0.005 0.7 0.482 − 0.006 0.014
Sex (male)
 Female 0.053 0.020 2.7 0.007 0.014 0.091
Race-ethnicity (NH White)
 NH Black − 0.147 0.160 − 0.92 0.359 − 0.461 0.167
 Native American 0.037 0.228 0.16 0.869 − 0.409 0.484
 Asian 0.018 0.136 0.13 0.894 − 0.248 0.284
 Hispanic 0.023 0.064 0.35 0.724 − 0.103 0.148
Education (< high school)
 High school − 0.224 0.062 − 3.62 0.000 − 0.346 − 0.103
 Some college − 0.234 0.058 − 4.01 0.000 − 0.348 − 0.120
 College graduate − 0.272 0.060 − 4.56 0.000 − 0.388 − 0.155
 Post baccalaureate − 0.273 0.062 − 4.4 0.000 − 0.394 − 0.151
Stress exposure (0–5) 0.179 0.012 15.33 0.000 0.156 0.202
PGS MDD 0.020 0.013 1.55 0.12 − 0.005 0.044
Stress*PGS − 0.015 0.011 − 1.31 0.189 − 0.037 0.007
Genetic ancestry
 PC1 0.055 0.063 0.87 0.382 − 0.068 0.178
 PC2 0.027 0.027 0.98 0.325 − 0.026 0.079
 PC3 − 0.020 0.018 − 1.11 0.268 − 0.054 0.015
 PC4 0.003 0.011 0.25 0.806 -0.019 0.0248
 PC5 − 0.000 0.009 − 0.02 0.981 − 0.019 0.018
Intercept 1.496 0.197 7.58 0.000 1.109 1.883

Stress*PGS is boldfaced to highlight. Reference category in brackets. Cell entries are as follows: b = unstandardized OLS regression estimates; se = standard error; t = test statistic; pr. ≤ two-tailed p-values; min and max = boundaries of the 95% confidence intervals. All data are weighted to reflect the design of the Add Health Study.