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. 2021 Oct 14;49(1):647–656. doi: 10.1007/s11033-021-06819-7

Fig. 2.

Fig. 2

Nanobodies neutralize the SARS-CoV-2. FC Fragment crystallizable, Fab fragment antigen-binding, VH Heavy chain variable domain, VL Light chain variable domain, CH heavy chain constant region, CL Light chain constant region, ACE2 angiotensin-converting enzyme 2. SARS-CoV-2 neutralization was made possible by inhibiting the target cell entrance. VHHs bind to the spike RBD and prevent the ACE2 engagement with RBD