FIGURE 10.

SCH530348 attenuated HR-induced chemokine production and NF-κB signaling activation in MLE-12 cells. Mouse lung epithelial cells were subjected to HR for 3 h and were treated with vehicle or 10 µM SCH530348. (A) HR-induced MLE-12 cells produced higher CXCL1/KC levels than control group cells, and SCH530348 significantly decreased chemokine production following HR for 3 h (B,C) SCH530348 significantly reduced HR-induced NF-κB p65 phosphorylation and IκB-α degradation. β-actin was used as an internal control. The data are expressed as the mean ± SD (n = 3 per group). *p < 0.05, **p < 0.01, ***p < 0.001 compared with the control group; ##p < 0.01, ###p < 0.001, compared with the HR group.