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. 2021 Sep 30;12:752507. doi: 10.3389/fphar.2021.752507

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Copyright © 2021 Chu, Tang, Pao, Wu and Liao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SCH530348 decreased IR-induced PAR-1 expression. (A) PAR-1 protein levels were determined by western blotting with specific antibodies. (B) IHC analysis of lung slices revealed that PAR-1 expression (indicated by arrowheads) was increased by IR injury compared with that of the control group. SCH530348 treatment decreased PAR-1 expression in the context of IR injury. The data are expressed as the mean ± SD (n = 4 per group). ***p < 0.001, compared with the control group; +++ p < 0.001, compared with the IR group.