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. 2021 Sep 30;12:752507. doi: 10.3389/fphar.2021.752507

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Copyright © 2021 Chu, Tang, Pao, Wu and Liao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SCH530348 downregulated IR-induced thrombin activity. (A) TAT levels in BALF were measured by ELISA. (B) Representative images showing IHC staining of thrombin in lung sections from the vehicle or IR group (200× magnification). Scale bars, 50 μm. TAT levels in BALF and thrombin-positive cells in lung tissue (indicated by arrowheads) were increased in the IR group compared with the control group. SCH530348 treatment mitigated these increases. The data are expressed as the mean ± SD (n = 6 per group). *p < 0.05, compared with the control group; ++ p < 0.01, compared with the IR group.