FIG. 7.

p38 MAPK-dependent expression of IL-6 in fibroblasts in response to EMCV infection or dsRNA. (A) IL-6 detection by ELISA. 3T3(neo) and 3T3(RNaseL) cells were grown and infected as described in Materials and Methods, and the appearance of IL-6 in the cell culture medium was assessed by ELISA as described in Materials and Methods. Error bars indicate standard deviation from experimental points in triplicate determinations. (B) Identical assessment of IL-6 expression 24 h after pI · pC treatment (0, 1, 3, or 10 μg/ml). Error bars indicate standard deviation from experimental points in triplicate determinations.