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. 2021 Sep 30;12:726707. doi: 10.3389/fphar.2021.726707

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Copyright © 2021 Ke, Li, Deng, Li, Wang, Lv and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metformin protects the mucus barrier by increasing the expression of mucins in ulcerative colitis (UC). RT-qPCR assay of mucin 2 (MUC2) expression of colon tissue (n = 3–4) (A), immunofluorescence assay showing the expression of mucin2 protein in colon tissue (scale bars, 200 μm) (n = 4) (B), and RT-qPCR assay (n = 3–6) of the relative expression levels of MUC1, MUC3, and MUC4 in colon tissue at mRNA level (C) and statistical comparison was made using an ANOVA test followed by Tukey-Kramer post-hoc tests. *p < 0.05, **p < 0.01, ***p < 0.001, ns, no significance.