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. 2021 Sep 30;12:726707. doi: 10.3389/fphar.2021.726707

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Copyright © 2021 Ke, Li, Deng, Li, Wang, Lv and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Akkermansia muciniphila alleviates dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. Flow chart of animal treatment (A), weight loss and gain during DSS treatment (n = 6–14) (B) and weight loss percentage at day 6 (n = 6–14) (C), disease activity index (DAI) scores (n = 6–14) (D), representative pictures of the mouse colon (n = 6–14) (E), colon length (n = 6–14) (F), hematoxylin and eosin (HE) staining of colon tissue (scale bars, 400 μm) (n = 6–10) (G), colon histological scores (n = 6–10) (H), and RT-qPCR assay of tumor necrosis factor-α (TNF-α) and interleukin 1β (IL1β) in colon tissue (n = 2–6) (I) and statistical comparison was made using an ANOVA test followed by Tukey-Kramer post-hoc tests. *p < 0.05, **p < 0.01, ***p < 0.001.