TABLE 1.

Mitochondrial Fe/S cluster assembly components.

Complex	Human	Yeast	Function	Location
ISCU complex	ISCUs	Isu1/Isu2	Scaffold protein	Mitochondria, cytoplasm and nucleus
	NFS1	Nfs1	Cysteine desulfurase provides the sulfur	Mitochondria, cytoplasm and nucleus
	ISD11	Isd11	Stabilize binding partner of NFS1	Mitochondria and nucleus
	ACPM	Acp1	Bind to and stabilize Isd11	Mitochondria
	Ferredoxin	Yah1	Electron donor	Mitochondria
	Frataxin	Yfh1	Regulates NFS1 activity	Cytoplasm and nucleus
Cluster transfer complex	HSPA9	Ssq1	Co-chaperone of GLRX5	Mitochondria and nucleus
	HSC20	Jac1	Co-chaperone of GLRX5	Mitochondria, cytoplasm and nucleus
	GLRX5	Grx5	Transfers 2Fe–2S clusters to client proteins	Mitochondria
	ABCB7	Atm1	Exports Fe–S clusters from mitochondria	Mitochondria
	ALR	Erv1	Exports Fe–S clusters from mitochondria	Mitochondria and cytoplasm
ISA complex	ISCA1	Isa1	Assemble 4Fe–4S clusters	Mitochondria
	ISCA2	Isa2	Assemble 4Fe–4S clusters	Mitochondria
	IBA57	Iba57	Assemble 4Fe–4S clusters	Mitochondria
	NFU1	Nfu1	Transfer 4Fe–4S clusters to target proteins	Mitochondria