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End resection versus end protection. 53BP1 protects DNA ends via its effector proteins, PTIP, RIF1, and Shieldin via (1) inhibition of EXO1 and DNA2 and (2) fill-in synthesis by the CST-Pol α. End protection is counteracted by BRCA1 via dephosphorylation of 53BP1 by PP4C.
