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. 2021 Sep 30;12:738230. doi: 10.3389/fgene.2021.738230

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Copyright © 2021 van de Kamp, Heemskerk, Kanaar and Essers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combination therapies targeting DDR pathways. (A) Inhibition of PARP1 leads to the conversion of SSBs into DSBs upon DNA replication. (B) An overview of NHEJ, TMEJ and HR and inhibitors targeting various components of these pathways.