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. 2021 Sep 30;12:729768. doi: 10.3389/fgene.2021.729768

Table 4.

Summary of lncRNA MIAT functional roles and related genes.

Cancer Expression Functional role Related genes References
Breast cancer Upregulate Cell proliferation and apoptosis DLG3 Li et al., 2020a
Cervical cancer Upregulate/ downregulate Cell proliferation and migration PI3K/Akt/mTOR miR-150-5p, CDKN1B Liu et al., 2020; Zhang et al., 2020b
Renal cell carcinoma Upregulate Cell proliferation and migration miR-29c, Loxl2 Qu et al., 2018
Gastric cancer Upregulate Cell proliferation and migration miR-141/DDX5 Sha et al., 2018; Xu et al., 2020
Leukemia Upregulate Cell proliferation and apoptosis miR-495 Wang et al., 2019a
Lung cancer Upregulate Cell migration, invasion, proliferation, metastasis miR-34a, miR-1246, MMP9, miR-184, miR-149-5p, FOXM1, miR-128-3p/PELI3 Lai et al., 2017; Fu et al., 2018; Lin et al., 2019; Li et al., 2020b; Wu et al., 2020; Zhou et al., 2020
Melanoma Upregulate Cell proliferation, invasion, and EMT miR-150 Zhu et al., 2020
Myeloma Upregulate Cell proliferation and apoptosis miR-29b Fu et al., 2019
Osteosarcoma Upregulate Cell proliferation, migration, invasion, and apoptosis miR-128-3p/VEGFC Zhang et al., 2019
Ovarian cancer Upregulate Cell proliferation and apoptosis miR-330-5p Shao et al., 2018
Pancreatic carcinoma Upregulate Cell proliferation and metastasis miR-133 Li et al., 2018b
Papillary thyroid cancer Upregulate Cell proliferation, migration, and invasion miR-212 Wang et al., 2019b
Tongue squamous cell carcinoma Upregulate EMT Wnt/β-catenin Zhong et al., 2019
Wilms' tumor Upregulate Cell migration and invasion DGCR8 Zhao et al., 2019