Table 4.
Summary of lncRNA MIAT functional roles and related genes.
| Cancer | Expression | Functional role | Related genes | References |
|---|---|---|---|---|
| Breast cancer | Upregulate | Cell proliferation and apoptosis | DLG3 | Li et al., 2020a |
| Cervical cancer | Upregulate/ downregulate | Cell proliferation and migration | PI3K/Akt/mTOR miR-150-5p, CDKN1B | Liu et al., 2020; Zhang et al., 2020b |
| Renal cell carcinoma | Upregulate | Cell proliferation and migration | miR-29c, Loxl2 | Qu et al., 2018 |
| Gastric cancer | Upregulate | Cell proliferation and migration | miR-141/DDX5 | Sha et al., 2018; Xu et al., 2020 |
| Leukemia | Upregulate | Cell proliferation and apoptosis | miR-495 | Wang et al., 2019a |
| Lung cancer | Upregulate | Cell migration, invasion, proliferation, metastasis | miR-34a, miR-1246, MMP9, miR-184, miR-149-5p, FOXM1, miR-128-3p/PELI3 | Lai et al., 2017; Fu et al., 2018; Lin et al., 2019; Li et al., 2020b; Wu et al., 2020; Zhou et al., 2020 |
| Melanoma | Upregulate | Cell proliferation, invasion, and EMT | miR-150 | Zhu et al., 2020 |
| Myeloma | Upregulate | Cell proliferation and apoptosis | miR-29b | Fu et al., 2019 |
| Osteosarcoma | Upregulate | Cell proliferation, migration, invasion, and apoptosis | miR-128-3p/VEGFC | Zhang et al., 2019 |
| Ovarian cancer | Upregulate | Cell proliferation and apoptosis | miR-330-5p | Shao et al., 2018 |
| Pancreatic carcinoma | Upregulate | Cell proliferation and metastasis | miR-133 | Li et al., 2018b |
| Papillary thyroid cancer | Upregulate | Cell proliferation, migration, and invasion | miR-212 | Wang et al., 2019b |
| Tongue squamous cell carcinoma | Upregulate | EMT | Wnt/β-catenin | Zhong et al., 2019 |
| Wilms' tumor | Upregulate | Cell migration and invasion | DGCR8 | Zhao et al., 2019 |