Figure 3.

Flow-chart of patient enrolment. Candidates eligible for inclusion were patients referred for advanced laboratory assessment of immunodeficiency at the department of Clinical Immunology, Aarhus University Hospital, Denmark between 12 May, 2011 and 18 August, 2016 (n = 687). Patients without an increased susceptibility to infections were excluded (n = 287). Patients younger than 16 years were excluded (n = 111) as diagnostic vaccination is not local practice in these patients. We also excluded patients who were referred from departments not specialized in immunodeficiency (n = 28). Patients without a previously archived plasma sample were also excluded (n = 32).