Figure 4.

Serotype-specific antibody levels in the patient serum samples. The concentrations (mg/L) of 12 different antibodies were determined in serum samples by a multiplex, bead-based assay. (A) The natural immunity of the patients (n = 154) displayed for each of the antibodies as continuous variables. The green area indicates concentrations of at least 1.3 mg/L, which is considered as ‘protective’ under AAAAI guidelines. Error bars are geometrical means with 95% confidence intervals. The antibodies were tested for different levels using repeated-measures ANOVA. (B) Data from previous panel showing the proportion of patients with antibody levels of at least 1.3 mg/L (i.e., ‘protective level’) for each specific antibody. (C) As in the panel A, but for levels measured in serum samples collected after PPV vaccination (n = 98). (D) Data from previous panel, showing the proportion of patients with antibody levels of at least 1.3 mg/L for each specific antibody.