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. 2021 Oct 7;3(4):fcab226. doi: 10.1093/braincomms/fcab226

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Results from disease progression modelling analyses. Subject numbers for each group are: Group 1 (223); Group 2 (108); Group 3 (76); Group 4 (43). Only continuous complete-case biomarker variables were used. No time scale is imposed on the event position (x-axis); events may be close together or distant in time. Positioning for all biomarkers of interest (y-axis) in all groups is presented. Each entry of each positional variance diagram corresponds to the probability each biomarker (y-axis) will become abnormal at each position in the sequence (x-axis) estimated by the SuStaIn EBM algorithm, ranging from 0 in white to 1 in black. Definitions: cerebrospinal fluid (CSF); amyloid beta 1–42 (Aβ); total tau (tau); phosphorylated tau 181 (p-tau); brain boundary shift integral atrophy rate over 12 months (BBSI); hippocampal boundary shift integral atrophy rate over 12 months (HBSI); Mini Mental State Examination (MMSE); logical memory immediate recall (LIMM).