Table 1.
Subject demographics and basic imaging information for the ADNI2/Go cohort
| C | SMC | EMCI | LMCI | Alzheimer’s disease | Group difference (P-value) | |
|---|---|---|---|---|---|---|
| N | 159 | 72 | 265 | 139 | 103 | |
| Age at baseline, years | 73.7 (6.2) | 72.0 (5.6) | 71.4 (7.3) | 71.9 (7.7) | 75.0 (7.8) | <0.001 |
| Male (%) | 46.5 | 44.4 | 54.3 | 54.0 | 59.2 | 0.2 |
| Hypertension (% hypertensive) | 51.6 | 41.7 | 50.9 | 44.6 | 45.6 | 0.4 |
| Smoking (% never/historical/current) | 60.4/35.9/3.8 | 52.8/44.4/2.8 | 60.4/38.1/1.5 | 67.6/30.2/2.2 | 64.1/32.0/3.9 | 0.4 |
| Body mass index, kg/m2 | 27.2 (4.3)b | 28.0 (6.4)a | 28.0 (5.3) | 27.4 (5.0) | 25.6 (4.2) | 0.001 |
| Percentage with diabetes | 6.9 | 12.5 | 11.3 | 8.6 | 8.8a | 0.5 |
| Percentage APOE ε4 carriers | 28.9 | 37.5 | 42.3 | 56.8 | 73.8 | <0.001 |
| Years of education | 16.5 (2.5) | 17.0 (2.4) | 16.0 (2.7) | 16.7 (2.5) | 15.7 (2.7) | <0.001 |
| First assessment MMSE | 29.0 (1.3) | 29.0 (1.2) | 28.3 (1.6) | 27.6 (1.9) | 23.1 (2.1) | Not appropriate |
| First assessment Trails A | 33.6 (10.5) | 34.7 (12.7) | 36.0 (12.7) | 41.7 (17.5) | 60.7 (33.7)a | <0.001 |
| First assessment Trails B | 82.7 (44.4)a | 87.0 (46.9) | 95.9 (45.7)d | 115.7 (63.2)c | 193.2 (86.5)h | <0.001 |
| First assessment LIMM | 14.3 (2.9) | 14.3 (3.3) | 11.0 (2.7) | 7.1 (3.0) | 4.0 (2.6) | <0.001 |
| Race (%) | ||||||
| Asian | 1.26 | 0.00 | 1.51 | 0.72 | 2.91 | |
| Native Hawaiian or Pacific | 0.00 | 0.00 | 0.38 | 0.72 | 0.00 | |
| Black or African American | 8.81 | 1.39 | 1.51 | 2.88 | 2.91 | |
| American Indian or Alaskan | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.2 |
| White | 88.68 | 95.83 | 93.96 | 94.96 | 93.20 | |
| More than one race | 1.26 | 2.78 | 1.51 | 0.72 | 0.97 | |
| Race unknown | 0.00 | 0.00 | 0.75 | 0.00 | 0.00 | |
| MRI follow-up time from baseline for whole brain atrophy rates (years) | 2.4 (1.3) | 1.7 (0.8) | 2.4 (1.3) | 2.2 (1.3) | 1.0 (0.5) | Not appropriate |
| Number of MRI visits for whole brain atrophy | 4.7 (1.2) | 2.8 (0.9) | 4.4 (1.2) | 4.5 (1.0) | 3.4 (1.0) | Not appropriate |
| Baseline WMH (ml) | 3.5 (4.9) | 3.6 (4.1) | 3.9 (6.9) | 3.6 (6.3) | 6.1 (8.9) | 0.01 |
| Lacunes n (%) | 3 (1.9)b | 1 (1.4)a | 11 (4.2)b | 0 (0.0)a | 2 (2.0)a | 0.1 |
| CMB (1 or more) n (%) | 27 (17.8)f | 6 (8.6)b | 36 (14.0)g | 17 (12.4)b | 21 (20.8)b | 0.2 |
| Whole-brain volume, ml | 1068 (105) | 1094 (88) | 1083 (108) | 1067 (101) | 1027 (117) | <0.001 |
| Total (left plus right) hippocampal volume, ml | 5.46 (0.65) | 5.68 (0.70)a | 5.43 (0.73)e | 5.09 (0.83) | 4.60 (0.71) | <0.001 |
Demographics are shown for controls, Early Mild Cognitive Impairment (EMCI), Late Mild Cognitive Impairment (LMCI), Subjective Memory Concern (SMC) and Alzheimer’s disease. Values are mean (SD) unless stated in the table, White matter hyperintensity (WMH) is reported as median (interquartile range). P-values represent the result of a single test over all groups.
LIMM, logical memory immediate recall score; MMSE, Mini-Mental State Examination.
a
Missing in 1 subject.
b
Missing in 2 subjects.
c
Missing in 3 subjects.
d
Missing in 4 subjects.
e
Missing in 5 subjects.
f
Missing in 7 subjects.
g
Missing in 8 subjects.
h
Missing in 12 subjects.