Table 2.

Results of the models of brain and hippocampal atrophy rate

	a) Whole-brain atrophy rate, ml/year		b) Hippocampal atrophy rate, ml/year
Control	5.3 [4.7, 5.9]		0.044 [0.036, 0.053]
SMC	5.3 [4.3, 6.3]		0.039 [0.019, 0.059]
EMCI	6.8** [6.2, 7.4]		0.058* [0.048, 0.069]
LMCI	9.3** [8.0, 10.5]		0.113** [0.094, 0.132]
Alzheimer’s disease	14.7** [12.9, 16.4]		0.185** [0.155, 0.215]
Change in atrophy rate	Individual models	Adjusted model	Individual models	Adjusted model
for a doubling of WMH volume	0.3 (0.01) [0.1, 0.6]	0.3 (0.03) [0.0, 0.6]	0.013 (<0.001) [0.009, 0.017]	0.013 (<0.001) [0.008, 0.017]
for one or more CMBs	1.5 (0.004) [0.5, 2.5]	1.4 (0.007) [0.4, 2.4]	0.029 (0.001) [0.013, 0.045]	0.021 (0.009) [0.005, 0.04]

The top half of the table represents mean [95% CI] atrophy rates in mls per year are shown for the 5 diagnostic groups. The atrophy rates are the mean predicted rate of change per year in each group calculated from the mixed model. The bottom half of the table shows the individual effects of WMH and CMBs on atrophy rates together with mutually adjusted associations that are also adjusted for lacunes. Results here are changes in atrophy rate for given increases in SVD, (P-value), [95% CI]. All models are adjusted for total intracranial volume. Values in the bottom half of the table are adjusted for diagnostic group.

EMCI, Early Mild Cognitive Impairment; LMCI, Late Mild Cognitive Impairment; SMC, Subjective Memory Concern; SVD, small vessel disease; WMH, white matter hyperintensity.

^* P-value represents a difference in rates from controls at P < 0.05.

^**Significantly different from controls P < 0.01.