Table 5.
Mean (SD) values of variables used in SuStaIn EBM according to groups (clusters) derived from the SuStaIn EBM algorithm
| Group 1 223 | Group 2 108 | Group 3 76 | Group 4 43 | |
|---|---|---|---|---|
| Aβ_1–42, pg/ml | 247.0 (83.9) | 271.5 (88.8) | 182.7 (44.1) | 300.7 (65.6) |
| Total Tau, pg/ml | 92.5 (49.9) | 65.0 (33.4) | 68.7 (32.7) | 54.0 (18.9) |
| Ptau_181, pg/ml | 28.7 (13.8) | 20.6 (10.6) | 25.0 (10.7) | 19.1 (6.2) |
| BBSI, mls/year | 6.7 (8.2) | 12.5 (5.2) | 6.6 (7.1) | 4.0 (7.1) |
| HBSI, mls/year | 0.07 (0.11) | 0.13 (0.12) | 0.06 (0.10) | 0.02 (0.10) |
| log2WMH, ml | 11.3 (1.2) | 12.5 (1.5) | 12.7 (1.4) | 11.5 (1.2) |
| MMSE,/30 | 27.8 (2.2) | 27.7 (2.3) | 29.0 (1.0) | 27.3 (2.6) |
| TrailsA,/150 | 36.1 (16.3) | 33.8 (10.2) | 41.8 (14.8) | 43.5 (19.7) |
| TrailsB,/300 | 94.5 (55.7) | 90.6 (39.7) | 117.4 (64.2) | 120.5 (61.4) |
| LIMM,/25 | 10.7 (4.4) | 10.1 (4.3) | 12.2 (3.5) | 7.5 (2.7) |
All values are derived from baseline measures apart from the BBSI and HBSI which was calculated from the baseline and 12-month interval scans.
BBSI, Brain Boundary Shift Integral; HBSI, Hippocampal Boundary Shift Integral; LIMM, logical memory immediate recall score; MMSE, Mini-Mental State Examination; WMH, white matter hyperintensity.