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. 2021 Sep 30;12:731048. doi: 10.3389/fimmu.2021.731048

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Copyright © 2021 Xu, Tang, Liu, Luo and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of risk signature based on the expression of HRLs. (A) The coefficient of 19 HRLs for the construction of risk signature. (B, C) The risk score and survival time of each sample in the TCGA (B) and CGGA (C) datasets. (D) Time-dependent ROC analysis of risk score in predicting 1-, 3-, and 5-year survival. (E, F) The expression of 19 HRLs in each sample from low risk to high risk in the TCGA (E) and CGGA (F) datasets. (G–J) The risk score in different grades (G), IDH status (H), 1p19q status (I), and MGMT status (J) of gliomas in the two datasets. ****p < 0.0001; ns, no significance.