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. 2021 Sep 30;12:731048. doi: 10.3389/fimmu.2021.731048

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Copyright © 2021 Xu, Tang, Liu, Luo and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Risk stratification correlated with the efficacy of immunotherapy. (A, B) The expression of several immune checkpoints in high-risk and low-risk groups in the TCGA (A) and CGGA (B) datasets. (C–E) Kaplan-Meier analyses of overall survival among four patient groups stratified by the HRL signature and PD-1 (C), PD-L1 (D), and CTLA-4 (E). (F) TIDE score of high-risk and low-risk groups in TCGA dataset. (G) Kaplan-Meier analysis of urothelial carcinoma patients stratified by HRL signature in IMvigor210 cohort. *p < 0.05, ***p < 0.001.