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. 2021 Sep 30;12:731048. doi: 10.3389/fimmu.2021.731048

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Copyright © 2021 Xu, Tang, Liu, Luo and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Risk signature was associated with tumor purity and immune infiltration. (A–D) The association between risk score and stromal score (A), immune score (B), ESTIMATE score (C), and tumor purity (D). (E, F) The abundance of 28 immune cells estimated by ssGSEA algorithm in high-risk and low-risk groups in TCGA (E) and CGGA (F) datasets. (G, H) The correlation between risk score and six immune cells estimated by TIMER algorithm in TCGA (G) and CGGA (H) datasets. (I, J) The abundance of 22 immune cells estimated by CIBERSORT algorithm in high-risk and low-risk groups in TCGA (I) and CGGA (J) datasets. *p < 0.05, **p < 0.01, ***p < 0.001, ns, no significance.