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. 2021 Sep 30;11:668661. doi: 10.3389/fonc.2021.668661

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Copyright © 2021 Abramov, Dru, Belykh, Park, Bardonova and Preul

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Line graphs show the relationship between (A) the brightness and (B) the contrast of the confocal laser endomicroscopy image and the decay of fluorescein sodium in minutes. The values are reported in units of optical density defined by Fiji open-source analytic software. Brightness is the mean gray value, calculated by the sum of the gray values of all the pixels in the selection divided by the number of pixels, and contrast is the standard deviation of gray values used to generate the mean. Used with permission from Barrow Neurological Institute, Phoenix, Arizona.