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. 2021 Sep 30;11:668661. doi: 10.3389/fonc.2021.668661

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Copyright © 2021 Abramov, Dru, Belykh, Park, Bardonova and Preul

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Case example of confocal laser endomicroscopy (CLE) images acquired after fluorescein sodium (FNa) redosing. (A) Coronal T1-weighted magnetic resonance image with contrast. Biopsy specimens were obtained from the enhancing tumor in the left frontal lobe. (B) A diagnosis of high-grade glioma was made on the basis of H&E staining of the biopsy specimens. (C) A CLE image acquired 95 minutes after initial FNa injection lacks clarity and was regarded as noninterpretable. (D) A histogram corresponding to the image in C shows intensity values of the CLE image acquired after the initial FNa dose. (E) A marked increase in brightness and contrast of the CLE image was observed after FNa redosing. (F) A histogram corresponding to E shows the intensity values of the CLE image acquired after FNa redosing. Count, number of pixels; Mean, brightness; StdDev, contrast; Min and Max, minimum and maximum gray values within the image; Mode, most frequently occurring gray value within the selection corresponds to the highest peak in the histogram. Used with permission from Barrow Neurological Institute, Phoenix, Arizona.