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. 2021 Sep 30;11:668661. doi: 10.3389/fonc.2021.668661

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Copyright © 2021 Abramov, Dru, Belykh, Park, Bardonova and Preul

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Case example of confocal laser endomicroscopy (CLE) images acquired after a single dose of fluorescein sodium (FNa) before the concept of redosing was introduced. (A) Coronal T1-weighted magnetic resonance image with contrast. Biopsy specimens were obtained from the enhancing tumor in the left frontal lobe. (B) A diagnosis of high-grade glioma was made on the basis of H&E staining of biopsy specimens. (C) A CLE image acquired 180 minutes after FNa injection is dark and noninterpretable. (D) A corresponding histogram shows the intensity values of the CLE image. Count, number of pixels; Mean, brightness; StdDev, contrast; Min and Max, minimum and maximum gray values within the image; Mode, most frequently occurring gray value within the selection corresponds to the highest peak in the histogram. Used with permission from Barrow Neurological Institute, Phoenix, Arizona.