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. 2021 Sep 30;11:668661. doi: 10.3389/fonc.2021.668661

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Copyright © 2021 Abramov, Dru, Belykh, Park, Bardonova and Preul

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Case example of CLE images acquired at a fluorescein sodium (FNa) dose of 40 mg/kg. (A) Axial T1-weighted magnetic resonance image with contrast. Biopsy specimens were obtained from the nonenhancing tumor in the left frontal lobe. (B) A diagnosis of low-grade glioma was made on the basis of H&E staining of biopsy specimens. (C) A CLE image acquired 90 minutes after FNa injection appears to be relatively dark, but tumor cells are still present. (D) A corresponding histogram shows the intensity values of the CLE image. Count, number of pixels; Mean, brightness; StdDev, contrast; Min and Max, minimum and maximum gray values within the image; Mode, most frequently occurring gray value within the selection corresponds to the highest peak in the histogram. Used with permission from Barrow Neurological Institute, Phoenix, Arizona.